1-Deoxynojirimycin and its derivatives: A mini review of the literature
H Wang, Y Shen, L Zhao, Y Ye - Current medicinal chemistry, 2021 - ingentaconnect.com
H Wang, Y Shen, L Zhao, Y Ye
Current medicinal chemistry, 2021•ingentaconnect.com1-Deoxynojirimycin (1-DNJ) is a naturally occurring sugar analogue with unique
bioactivities. It is found in mulberry leaves and silkworms, as well as in the metabolites of
certain microorganisms, including Streptomyces and Bacillus. 1-DNJ is a potent α-
glucosidase inhibitor and it possesses anti-hyperglycemic, anti-obese, anti-viral and anti-
tumor properties. Some derivatives of 1-DNJ, like miglitol, miglustat and migalastat, were
applied clinically to treat diseases such as diabetes and lysosomal storage disorders. The …
bioactivities. It is found in mulberry leaves and silkworms, as well as in the metabolites of
certain microorganisms, including Streptomyces and Bacillus. 1-DNJ is a potent α-
glucosidase inhibitor and it possesses anti-hyperglycemic, anti-obese, anti-viral and anti-
tumor properties. Some derivatives of 1-DNJ, like miglitol, miglustat and migalastat, were
applied clinically to treat diseases such as diabetes and lysosomal storage disorders. The …
1-Deoxynojirimycin (1-DNJ) is a naturally occurring sugar analogue with unique bioactivities. It is found in mulberry leaves and silkworms, as well as in the metabolites of certain microorganisms, including Streptomyces and Bacillus. 1-DNJ is a potent α-glucosidase inhibitor and it possesses anti-hyperglycemic, anti-obese, anti-viral and anti-tumor properties. Some derivatives of 1-DNJ, like miglitol, miglustat and migalastat, were applied clinically to treat diseases such as diabetes and lysosomal storage disorders. The present review focused on the extraction, determination, pharmacokinetics and bioactivity of 1-DNJ, as well as the clinical application of 1-DNJ derivatives.
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